RESEARCH ARTICLE


The Renin Angiotensin System and the Metabolic Syndrome



Chih-Hong Wang, Feng Li, Nobuyuki Takahashi*
Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, 819 Brinkhous-Bullitt Building, Chapel Hill, NC 27599-7525, USA


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© 2010 Wang et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, 819 Brinkhous-Bullitt Building, Chapel Hill, NC 27599-7525, USA; Tel: 919-966-1338; Fax: 919-966-8800; E-mail: ntakaha@med.unc.edu


Abstract

The renin angiotensin system (RAS) is important for fluid and blood pressure regulation. Recent studies suggest that an overactive RAS is involved in the metabolic syndrome. This article discusses recent advances on how genetic alteration of the RAS affects cardiovascular and metabolic phenotypes, with a special emphasis on the potential role of angiotensin-independent effects of renin.

Keywords: (Pro) renin receptor, body fat, fecal fat, thermogenesis.