The Emergence of Ambulatory Measurement of Arterial Stiffness and Central Blood Pressure. A Promising Novelty of Clinical Importance or Just Another Marker?

A. Lazaridis1, E. Gkaliagkousi1, *, M. Doumas1, 2, A. Reklou1, A. Karagiannis 1
1 2nd Propedeutic Department of Internal Medicine, Aristotle University, Thessaloniki, Greece
2 Veteran Administration Medical Center and George Washington University, Washington, DC, USA

© 2013 Lazaridis et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Internal Medicine, Aristotle University, Konstantinoupoleos 49 str. Thessaloniki, 546 42, Greece; Tel: +302310 892108; Fax: +302310 835955; Email:


Whereas brachial blood pressure (BP) is still considered the gold standard for the estimation of cardiovascular risk in all clinical trials and guidelines, scientific interest is shifting towards central hemodynamics and the scientific community is experiencing a whole new revolution with the emergence of novel cardiovascular markers such as the ambulatory measurement of central BP and arterial stiffness. Central BP has already started to demonstrate its superiority over peripheral BP as a better and more reliable predictor of end-organ damage in cardiovascular diseases. Furthermore, ambulatory measurement of central BP and pulse wave velocity are expected to add much more useful information towards a more integrated assessment of cardiovascular risk and profile. However, more research is required before these novel markers could be incorporated in the everyday practice of BP measurement.

Keywords: Ambulatory monitoring, arterial stiffness, cardiovascular risk, central blood pressure, pulse wave velocity.