Pathophysiology of Early Vascular Ageing-Opportunities for Treatment

Vasilios Kotsis1, *, Christina Antza1, Stella Stabouli1, 2
1 Hypertension Center, 3rd Department of Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Greece
2 1st Department of Pediatrics, Hippokration Hospital, Aristotle University Thessaloniki, Greece

© 2013 Kotsis et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Hypertension-ABPM Center Papageorgiou Hospital, Zaka 39, Panorama 55236, Thessaloniki, Greece; Tel: +30 6974748860; Fax: +30 2310452429; E-mail:


The story of vascular ageing was first described in the seventeenth century when Thomas Sydenham wrote that ‘A man is as old as his arteries’. This aphorism was returned to publicity lately when Peter Nilsson reintroduced the concept of early vascular ageing. As vascular ageing is described a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modification of the signals that modulate them. In susceptible individuals this process appears to be accelerated, leading to features that comprise a condition characterized as early vascular aging (EVA). Early vascular ageing represents the acceleration of the vascular ageing process.

Keywords: Arterial stiffness, ageing, early vascular ageing.