RESEARCH ARTICLE


Association of Insulin Secretion Level on Lipid Fractions and Risk of Arterial Hypertension



Majda Dali-Sahi1, Nouria Dennouni-Medjati1, Youssouf Kachekouche1, *, Hamza N.M. Boudia1, Houssam Boulenouar2
1 Departement of Biology, Analytical Chemistry and Electrochemistry Laboratory, University of Tlemcen, Tlemcen, 13000, Algeria
2 Cancer Laboratory, University of Tlemcen, Tlemcen, 13000, Algeria

Article Information


Identifiers and Pagination:

Year: 2019
Volume: 11
First Page: 6
Last Page: 10
Publisher Id: TOHYPERJ-11-6
DOI: 10.2174/1876526201911010006

Article History:

Received Date: 03/03/2018
Revision Received Date: 6/08/2019
Acceptance Date: 29/08/2019
Electronic publication date: 30/09/2019
Collection year: 2019

© 2019 Dali-Sahi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Departement of Biology, Analytical Chemistry and Electrochemistry Laboratory, University of Tlemcen, 13000, Algeria; Tel: (+213) 799203413; E-mail: Youcef.kache13@gmail.com


Abstract

Background:

The existing literature reports results on the association of lipid parameters with the level of insulin secretion and the risk of arterial hypertension.

Objective:

This study evaluated the role of the insulin dosage and lipid fractions in the risk of arterial hypertension in type 2 diabetic patients in Western Algeria.

Methods:

This was a cross-sectional observational study involving 101 subjects with type 2 diabetes mellitus. The data collected was about the biodemographic profile of the participants. We performed multiple regressions to test the effect of insulin concentration on the parameters studied.

Results:

The multiple regression analytical study showed that HOMA-IR, BMI and waist circumference were predictors for the insulinemia response variable (P<0.05). It should be noted that in insulinopenia, insulin secretion is positively and significantly correlated with non-HDL-C (P=0.037), and it is also significantly and positively correlated with LDL-C (P=0.042). Multiple regression also shows that SBP and DBP are significantly and positively related to insulin resistance. Our data suggest a possible direct relationship between fasting insulin and blood pressure.

Conclusion:

Monitoring of circulating insulin concentrations is critically important in a population of type 2 diabetics.

Keywords: High blood pressure, Non-HDL-C, Type 2 diabetes mellitus, CARDIA, Algeria, Insulin.