Association of Insulin Secretion Level on Lipid Fractions and Risk of Arterial Hypertension

Majda Dali-Sahi1, Nouria Dennouni-Medjati1, Youssouf Kachekouche1, *, Hamza N.M. Boudia1, Houssam Boulenouar2
1 Departement of Biology, Analytical Chemistry and Electrochemistry Laboratory, University of Tlemcen, Tlemcen, 13000, Algeria
2 Cancer Laboratory, University of Tlemcen, Tlemcen, 13000, Algeria

© 2019 Dali-Sahi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Departement of Biology, Analytical Chemistry and Electrochemistry Laboratory, University of Tlemcen, 13000, Algeria; Tel: (+213) 799203413; E-mail:



The existing literature reports results on the association of lipid parameters with the level of insulin secretion and the risk of arterial hypertension.


This study evaluated the role of the insulin dosage and lipid fractions in the risk of arterial hypertension in type 2 diabetic patients in Western Algeria.


This was a cross-sectional observational study involving 101 subjects with type 2 diabetes mellitus. The data collected was about the biodemographic profile of the participants. We performed multiple regressions to test the effect of insulin concentration on the parameters studied.


The multiple regression analytical study showed that HOMA-IR, BMI and waist circumference were predictors for the insulinemia response variable (P<0.05). It should be noted that in insulinopenia, insulin secretion is positively and significantly correlated with non-HDL-C (P=0.037), and it is also significantly and positively correlated with LDL-C (P=0.042). Multiple regression also shows that SBP and DBP are significantly and positively related to insulin resistance. Our data suggest a possible direct relationship between fasting insulin and blood pressure.


Monitoring of circulating insulin concentrations is critically important in a population of type 2 diabetics.

Keywords: High blood pressure, Non-HDL-C, Type 2 diabetes mellitus, CARDIA, Algeria, Insulin.